Numerous hospitals have documented their experience with Curos passive disinfection, citing reductions in catheter-related bloodstream infections, contaminated blood cultures, and the associated costs of care.
Download Annotated Bibliography of Independent Hospital Studies.
AJIC December 2012: Impact of alcohol-impregnated port protectors and needleless neutral pressure connectors on central line-associated bloodstream infections and contamination of blood cultures in an inpatient oncology unit
- A total of 6,851 central line-days and 16 CLABSIs (2.3 infections/1,000 central line days) were documented during the control period, compared with 3,005 central line days and one CLABSI (a rate of 0.3 infections/1,000 central line days) during the intervention period (relative risk, 0.14; 95% confidence interval [CI], 0.02-1.07; P = .03).
- The rate of contaminated blood cultures from central lines was 2.5% (17 of 692) during the control period, but only 0.2% (1 of 470) during the intervention period (relative risk, 0.09; 95% CI, 0.01-0.65; P = .002).
- The rate of adherence to the intervention was 85.2% (228 of 269 patients with catheter protectors).
- This 32-bed study showed $500,000 in annualized savings (Sweet MA, et al. SHEA Product Evaluation 2011).
Citation: Sweet, MA; Cumpston A; Brigg, F, Craig M and Hamadani M. Impact of alcohol-impregnated port protectors and needleless neutral pressure connectors on central line-associated bloodstream infections and contamination of blood cultures in an inpatient oncology unit. American Journal of Infection Control: Volume 40 Number 10; December 2012
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JAVA December 2012: Central Venous Catheter Protective Connector Caps Reduce Intraluminal Catheter-Related Infection
- During 2010, the CLABSI rate reduced from 1.9 in 2010 to 0.5 during the one-year trial period.
- The implementation of Curos Strips during month five of the trial increased compliance rates from 63% to 80%.
Citation: Ramirez C, Lee AM, Welch K. Central Venous Catheter Protective Connector Caps Reduce Intraluminal Catheter-Related Infection. The Journal of the Association for Vascular Access: Volume 17 Number 4; December 2012
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Alcohol-Impregnated Disinfectant Caps Reduce the Rate of Central-Line Associated Bloodstream Infections and Nosocomial Bacteremia
- CLABSI decreased 67% (From a rate of 1.5 to a rate of 0.5)
- Nosocomial BSI decreased 36% (From a rate of 0.73 to rate of 0.47)
- Only 33% of all noted Nosocomial BSI’s were reported as a CLABSI
Mark Shelly, Linda Greene, Lynne Brown, Sherry Romig, Ann Marie Pettis.
Highland Hospital and University of Rochester Medicine, Rochester, NY
Presented at SHEA ID Week 2014
Reducing Central Line-Associated Bloodstream Infections through the Addition of Disinfecting Port Protector Caps to the Central Line Bundle
- Curos disinfecting port protectors were implemented as part of the central line bundle to prevent CLABSI on an Acute Inpatient Oncology Unit.
- Audits were conducted to track cap compliance which rose steadily to over 90%.
- CLABSIs rates decreased on both units.
Jean Shiber MN, RN-BC, OCN , Gina Jolicoeur RN, OCN, Tere Crouchet MSN, RNBC, CCTN; Acute Oncology Unit, Ochsner Medical Center, New Orleans LA
Presented at Ochsner Research Day, May 20, 2014
The effect of 70% isopropyl alcohol port protection on central venous catheter related infection in patients on home parenteral nutrition
- After the implementation of Curos, the monthly infection rate declined significantly from a mean of 1.36/1000 catheter days to 0.47/1000 catheter days (65.4%.)
- 99.6% of the patients who agreed to use Curos were extremely happy with the product and only 2 (0.7%) patients were non-compliant.
- The use of Curos was significant in reducing house-wide CLABSIs, as well as increasing staff satisfaction and impacting cost.
Mia Small, MSc, BSc (Hons), RGN, DipNutr, RNutr, St. Mark’s Hospital, Harrow, UK
2014 World Congress of Vascular Access
A Significant Decline in Central Line-Associated Blood Stream Infections Using Alcohol-Impregnated Port Protectors at a Large Non-Profit Acute Care Hospital
- In the first 10 months of hospital wide use of Alcohol-Impregnated Port Protectors (AIPPs), CLABSI rates decreased by 68% compared to the 10 months prior to AIPPs use.
- This process improvement step was significant in reducing house wide CLABSIs, as well as increasing staff satisfaction and impacting cost.
Barbara Danielson, BSN, RN, CIC, Texas Health; Sharon Williamson, MT(ASCP)SM, CIC, Texas Health Resources; Gurminder Kaur, MSN, RN, CIC, Texas Health Presbyterian Hospital Dallas; Noreen Johnson, BSN, RN, CIC, Texas Health
2014 APIC Annual Conference
Implementing Alcohol Impregnated Port Protectors as a Means to Decrease CLABSI’s
• Excluding mucosal barrier injuryrelated laboratory-confirmed bloodstream infections (MBI-LCBIs), the adjusted CLABSI rate on a 36-bed medical oncology unit fell from 1.8 infections per 1,000 central line days in 2012 to 0.6 infections per 1,000 central line days in 2013 (66.7% reduction).
Morgan Miskill, RN, BSN, OCN and Emily Bellard, RN, MSN, OCN; Carolinas HealthCare System
2014 ONS Congress
Intermountain Medical Center: Decreasing CLABSI Rates and Cost Following Implementation of a Disinfectant Cap in a Tertiary Care Hospital
- Significant decrease in the rate of CLABSI and contaminated blood cultures from 2011 to 2012.
- The facility estimated an annual cost savings of $732,840 using Curos.
Sharon Sumner, RN, BSN, IP; Lorraine Linford, RN, BS, CNSC; Carrie Taylor, RN, MSN, CIC; BYU College of Nursing: Katreena Merrill, RN, PhD
APIC June 2013
Texas Health Presbyterian Hospital: Decreasing the Incidence of Central Line-Associated Blood Stream Infections using Alcohol-Impregnated Port Protectors (AIPPS) in a Neonatal Intensive Care Unit
- In the 1st quarter of 2011, a 47-bed, level III NICU switched from a traditional 15-second catheter scrub using alcohol wipes to using CUROS® 70% isopropyl alcohol-impregnated port protectors.
- By the end of 2011, the CLABSI Standardized Infection ratio (SIR) had fall from the 2010 calculation of 1.723 to 1.013 (or 1% above the expected). The 2011 results included a 4th quarter SIR of 1.656 when CUROS port protectors were NOT in use. When the hospital resumed CUROS use in January 2012, the annual SIR was calculated to be 0.722 (28% below expected).
Barbara Danielson, BSN, RN, CIC; Sharon Williamson, MT (ASCP) SM, CIC; Gurminder Kaur, MSN,RN, CIC; Christine Brooks, MSN, RNC-NIC, NE-BC; Phyllis Scholl, BSN, RNC; Andrea Baker, BSN, RNC
Providence Sacred Heart Medical Center and Children’s Hospital: Achieving Zero coagulase-negative staphylococcus (CoN) CLBSI in the NICU
- Five CoN positive cultures were documented in the pre-intervention period (July – March 2012), for a rate of 1.6 CoN infections per 1,000 line days as compared to two CoN positive cultures during the CUROS trial conducted from April-December 2012.
- The trial resulted in an estimated nine-month cost savings of $87,468.
- Zero CoN CLBSI were reported in the first quarter of 2013.
Jean Kelleher, Roy Almeida, Heidi Cooper, Susan Stauffer
Providence Sacred Heart Medical Center: Impact of Port Protectors on Incidence of Central Line Infections
- During a three-month trial on all patients, all lines in the adult ICU, the CLABSI rate fell from 2.6/1000 device days for the previous quarter to zero/1000 device days during the pilot period. The CLABSI rate for the control unit (CICU) for the same pilot period was 3.9/1000 device days.
- In the six months since the product was implemented across all critical care units at PSHMC, there have been zero CLABSI in the CICU and two CLABSI events in the ICU – both were determined to be unrelated to the use of Curos.
Mary Jo Moore, RN MA; Kim Gripp, RN; Heidi Cooper, RN MS; Roy Almeida PhD
Legacy Health: Forcing the Function: Implementation and Evaluation of an IV Port Protector to Decrease CLABSI
- From September 2011 to February 2012 all four nursing units using Curos decreased the incidence of CLABSI by 50% or greater and contaminated blood cultures by 30% or greater.
- The facility estimated that the trial units saved Legacy Health $103,524 over six months.
Mary Davis, BSN, RN, CCRN
National Teaching Institute & Critical Care Exposition 2013
Grady Health System: Decreasing Central Line Associated Blood Stream Infections (CLABSI) in Adult ICUs through Teamwork and Ownership
- The average rate of CLABSI in the SICU decreased from 9.2 CLABSI/1000 central line days in the 10 months prior to Curos implementation to 5.1 CLABSI/1000 central line days in the 10 months since implementation — a 45% decrease.
- The average rate of CLABSI in the MICU decreased from 9.5 CLABSI/1000 central line days in the 10 months prior to Curos implementation to 3.9 CLABSI/1000 central line days in the 10 months since implementation — a 59% decrease.
M Cole, BSN, CIC; K Kennedy, MN, RN, NEA-BC
GHA Patient Safety Summit 2013
California Children’s Services (CCS) Neonatal Infection Prevention Project in Association with, California Perinatal Quality Care Collaborative (CPQCC): 2006-2012 Update
- CLABSIs fell 70% to 0.65/1000 line days during the study period. Results at some NICUs suggest a sustained “zero” CLABSI rate
- target is achievable even in complex Regional NICU environments.
- CLABSI rates continue to fall significantly for the “All Birth Weights” category
California Children’s Services
Vermont Oxford Network 2012
Barnes Jewish Hospital: Impact of Alcohol-Impregnated Protectors on Incidence of Catheter-Associated Bloodstream Infections
- Intervention Ward: There were 22,662 line days (11,213 pre, 11,449 post-intervention). The monthly median CABSI rate was 5.3 (range: 3.1–7.2) pre- and 3.7 (range: 1.0–7.2) post- intervention period. The pre-intervention CABSI rate linear trend was 0.21 (95% CI: 0.05, 0.37) and the post-intervention trend was – 0.19 (95%CI:-0.35,-.02).
- Control Ward: There were 17,670 line days (8,913 pre- and 8,757 post-intervention). The monthly median CABSI rate was 5.6 (range: 2.6 – 10.3) pre and 5.4 (range: 2.7 – 11.3) post-intervention. The pre-intervention CABSI rate linear trend was 0.06 (95% CI: – 0.19, 0.32) and the post-intervention trend was – 0.04 (95%CI:-0.29, 0.22).
- Addendum: Following discontinuation of the product, the CABSI rate on the intervention unit returned to its pre-intervention rate. The control unit CABSI remained the same.
Washington University in St. Louis School of Medicine: F Alasmari, MD, MSc; ND Kittur PhD, MPH; ER Dubberke, MD, MSPH; Barnes Jewish Hospital: AJ Russo, MPH; KM McMullen, MPH, CIC; K Rensing, RN, MSN, ANP-BC, CRNI; JL Mayfield, BSN, MPH, CIC
Rady Children’s Hospital: Reduction of Central Line Associated Bloodstream Infection (CLABSI) in a Neonatal Intensive Care Unit with Use of Access Site Disinfection Caps
- Compared to the pre-intervention period, during the 12 months the Access Site Disinfection Caps (ASDC) were in use the CLABSI rate decreased from 0.93 infections per 1000 line days to 0.30 per 1000 line days (68%).
- The number of blood isolates meeting criteria as contaminants decreased from 3.6 to 2.7 per 1000 line days and the number of CLABSIs due to coagulase negative Staphylococci decreased from four of seven CLABSI the previous year to causing one of the two CLABSI during the year of product use.
Alice Pong, MD; Cindy Salgado, BSN, PHN, MBA, CIC; Mark Speziale, MD, PhD; Peggy Grimm, MS, RNC-NIC; Chris Abe, BSN, CIC
Infection Control Today (2010): Disinfecting Needleless Access Valves – Improve Practice and Decrease CRBSIs: Three Hospitals’ Experience With a New Technology
This article explores luer-activated valve disinfection technology advances. Clinical experience with disinfection caps is described at three medical centers: Sharp Chula Vista Medical Center, Chula Vista, Calif., Rady Children’s Hospital, San Diego, Calif., and Miller Children’s Hospital, Long Beach, Calif.
Temple University Hospital Clinical Case: Clinical Support for All Patients, All Lines, All the Time (AAA)
- In the three-month period, there were four CLABSI cases reported on the units trialing the passive disinfection device as compared to 11 cases that were reported in the same timeframe the previous year – a 63.6% reduction.
- An All patients, All lines, All the time (AAA) policy created greater compliance than did a central line-only approach due to less confusion for the staff.
- Curos was approved for implementation hospital-wide in February 2012.
Mary Doherty, RN, MBA, CIC and Patricia Heys, BS
REACHING ZERO: Strategies and Tools Utilized to Eliminate Preventable Bloodstream Infections
Written by Hartford Hospital clinicians, Lee Steere, RN, CRNI, of the IV Therapy Services Department and Joyce Sauvé, RN, CIC, an Epidemiology Clinician within the Infection Control Department, this paper outlines The Hartford Hospital experience addressing CLABSI and best practices tools for CLABSI rate reduction.
Lee Steere, RN, CRNI and Joyce Sauvé, RN, CIC
The Role of Technology in Reducing Risks Associated with CRBSI
Authored by Darcy Doellman, BSN, RN, CRNI, aVascular Access Nurse at Cincinnati Children’s Hospital, this paper explores the risk factors for CRBSI including type of catheter, insertion site selection, intermittent Infusions, needleless connectors as well as the pathophysiology of CRBSI. She discusses a broad array of proven CRBSI prevention efforts including process and technology solutions.
Darcy Doellman, BSN, RN, CRNI